Lycopene CAS:502-65-8 CAS:Lycopene,502-65-8

  • Product Name:Lycopene
  • CAS:502-65-8
  • Molecular formula:C40H56
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Lycopene CAS:502-65-8 CAS:Lycopene,502-65-8

Lycopene CAS:502-65-8 CAS:Lycopene,502-65-8 Basic information

Product Name: Lycopene
Synonyms: Lycopene 502-65-8;LYCOSOURCE;LYCOPENE;JARCOPENE(TM);4,4-CAROTENE;2,6,10,14,19,23,27,31-OCTAMETHYL-DOTRIACONTA-2,6,8,10,12,14,16,18,20,22,24,26,30-TRIDECAENE;PSI,PSI-CAROTENE;Y,Y-CAROTENE
CAS: 502-65-8
MF: C40H56
MW: 536.87
EINECS: 207-949-1
Product Categories: Plant extract;from Blakeslea Trispora;Plant extracts;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;BENUTRI;Carotenoids;All Aliphatics;Natural Plan
Mol File: 502-65-8.mol

Lycopene CAS:502-65-8 CAS:Lycopene,502-65-8 Chemical Properties

density: 0.9380 (estimate)
Melting point: 172-173°C
Boiling point: 644.94°C (rough estimate)
form: powder
storage temp.: −70°C
InChIKey: OAIJSZIZWZSQBC-BOJOQWLHSA-N
Stability: Heat sensitive - store at -70 C. Combustible. Incompatible with strong oxidizing agents.
FEMA: 4110 | TOMATO LYCOPENE
CAS DataBase Reference: 502-65-8(CAS DataBase Reference)

Lycopene

96%

98.67%

Quality Data  质量数据

Appearance 外观

Violet-brown to violet-red powder

Conforms

Loss on Drying 干燥失重

0.4%

0.11%

Ash 灰分

≤0.4%

0.12%

Heavy Metals 重金属

10ppm

Conforms

Lead(Pb)

2ppm

Conforms

Arsenic(As)

1ppm

Conforms

Cadmium(Cd)

1ppm

Conforms

Mercury(Hg)

0.1ppm

Conforms

Microbiological Data  微生物数据

Total Plate Count 菌落总数

1000cfu/g

Conforms

Moulds and Yeast 霉菌酵母菌

100cfu/g

Conforms

E.Coli 大肠杆菌

30 MPN/100g

Conforms

Salmonella 沙门氏菌

Negative

Conforms

Addition Data

Packing 包装规格

1kg/bag, 25kg in one type cardboard drum.

Storage 储藏条件

Store in a cool dry place, avoiding sunlight directly 阴凉避光储存

Shelf Life 有效期限

Two Years 2

Lycopene Usage And Synthesis
Chemical PropertiesLycopene is a white to pale-yellow solid; balsam oriental aroma. Lycopene extract from tomato is a dark-red viscous liquid. It is freely soluble in ethyl acetate and n-hexane, partially soluble in ethanol and acetone, and insoluble in water. A solution in n-hexane shows an absorption maximum at approximately 472nm.
Lycopene (from the Greek word lykopersikon, meaning tomato) is a bright red carotene and carotenoid pigment. The natural resources are red fruits and vegetables, such as tomatoes, pink grapefruit, watermelon, and apricots. After absorbing from the stomach, lycopene is transported in the blood and accumulates in the liver, adrenal glands, and testes. Lycopene has been used to prevent carcinogenesis, cardiovascular diseases and aging.

From a chemistry perspective, lycopene is a symmetrical tetraterpene assembled from 8 isoprene units, containing 11 conjugated and 2 non-conjugated double bonds between carbon atoms. Lycopene is a member of the carotenoid family, and the predominant source in the human diet comes from tomato and tomato-based products. The antioxidant capacity of tomato strongly depends on the content and bioavailability of lycopene in the fruit. There is strong correlation between lycopene content in tomatoes and antioxidant capacity.
OccurrenceLycopene is a carotenoid that occurs naturally in tomatoes.
UsesCarotenoid antioxidant occurring in ripe fruit, especially in tomatoes.
UsesLycopene extract from tomato is intended for use as a food colour. It provides the similar colour shades, ranging from yellow to red, as do the natural and synthetic lycopenes. Lycopene extract from tomato is also used as a food/dietary supplement in products where the presence of lycopene provides a specific value (e.g., antioxidant or other claimed health benefits). The product may also be used as an antioxidant in food supplements.
Lycopene extract from tomato is intended for use in the following food categories: baked goods, breakfast cereals, dairy products including frozen dairy desserts, dairy product analogues, spreads, bottled water, carbonated beverages, fruit and vegetable juices, soybean beverages, candy, soups, salad dressings, and other foods and beverages.
DefinitionChEBI: An acyclic carotene commonly obtained from tomatoes and other red fruits.
Production MethodsLycopene extract from tomato is produced from a tomato variety with high lycopene content, within the range of 150 to 250 mg/kg. This particular variety is not generally marketed for direct consumption, but is used primarily in the production of this lycopene extract. The extract is produced by crushing tomatoes into crude tomato juice that is then separated into serum and pulp. The tomato pulp is then extracted with ethyl acetate. The final product is obtained after solvent removal by evaporation under vacuum at 40-60°C.
Aroma threshold valuesMedium strength odor, balsamic type; recommend smelling in a 1.0% solution or less.
Biological ActivityLycopene may act as an inhibitor of tumor cells. In one study, lycopene was shown to inhibit PDGF-BB-induced signalling and cell migration in human cultured skin fibroblasts (Wu et al., 2007). Trapping of PDGF by lycopene compromised melanoma-induced fibroblast migration and attenuated signalling transduction in fibroblasts (Wu et al., 2007). In functional studies, lycopene inhibited melanoma-induced fibroblast migration in a noncontact coculture system and attenuated signalling in fibroblasts simulated by melanoma-derived conditioned medium (Chiang et al., 2007).
Mechanism of actionThe biological activities of carotenoids such as βcarotene are related in general to their ability to form vitamin A within the body.Since lycopene lacks the β-ionone ring structure, it cannot form vitamin A.Its biological effects in humans have therefore been attributed to mechanisms other than vitamin A. Two major hypotheses have been proposed to explain the anticarcinogenic and antiatherogenic activities of lycopene: nonoxidative and oxidative mechanisms.
Among the nonoxidative mechanisms, the anticarcinogenic effects of lycopene have been suggested to be due to regulation of gap-junction communication in mouse embryo fibroblast cells.Lycopene is hypothesized to suppress carcinogen-induced phosphorylation of regulatory proteins such as p53 and Rb antioncogenes and stop cell division at the G0–G1 cell cycle phase.Astorg and colleagues proposed that lycopene-induced modulation of the liver metabolizing enzyme, cytochrome P4502E1, was the underlying mechanism of protection against carcinogen-induced preneoplastic lesions in the rat liver. Preliminary in vitro evidence also indicates that lycopene reduces cellular proliferation induced by insulin-like growth factors, which are potent mitogens, in various cancer cell lines.Regulation of intrathymic T-cell differentiation (immunomodulation) was suggested to be the mechanism for suppression of mammary tumour growth by lycopene treatments in SHN retired mice.Lycopene also has been shown to act as a hypocholesterolemic agent by inhibiting HMG–CoA (3-hydroxy-3-methylglutaryl–coenzyme A) reductase.
Lycopene has been hypothesized to prevent carcinogenesis and atherogenesis by protecting critical cellular biomolecules, including lipids, lipoproteins, proteins and DNA.In healthy human subjects, lycopene- or tomatofree diets resulted in loss of lycopene and increased lipid oxidation,whereas dietary supplementation with lycopene for 1 week increased serum lycopene levels and reduced endogenous levels of oxidation of lipids, proteins, lipoproteins and DNA.Patients with prostate cancer were found to have low levels of lycopene and high levels of oxidation of serum lipids and proteins.
Anticancer ResearchLycopene is a naturally occurring chemical that manifests as a red pigment contained in common foods such as tomatoes, pink grapefruits, guava, and watermelon (Giovannucci 1999). This is a very strong antioxidant that has been found to prevent and even reverse the progression of prostate cancer, as well as treating benign prostatic hyperplasia. In a recent study, 30 mg a day of lycopene showed curative results in prostate cancer. For best results, supplements are recommended alongside eating and drinking plenty of lycopene-containing food and juices (Jatoi et al. 2007). Earlier research showed that taking a specific combination of lycopene, selenium, and saw palmetto by mouth for 8 weeks reduced pain in men with prostate swelling and pelvic pain more significantly than saw palmetto alone (Feifer et al. 2002).Lycopene shows anticancer activity against prostate, endometrial, breast, and colon carcinomas. It inhibits human cancer cell proliferation by activation of cancer-preventive enzymes like phase II detoxification enzymes, by suppression of insulin-like growth factor-I-stimulated growth (Wang et al. 2012). It also activates antioxidant enzymes like GST, GSH, and GPx and protects from oxidative stress caused by carcinogens. It alters PI3K/AKT pathway and ERK and Bcl-2 signaling in pancreatic and gastric carcinoma cells, respectively (Singh et al. 2016b).
Purification MethodsCrystallise lycopene from CS2/MeOH, diethyl ether/pet ether, or acetone/pet ether. Also purify it by column chromatography on deactivated alumina, CaCO3, calcium hydroxide or magnesia. It is oxygen sensitive and is stored in the dark, in an inert atmosphere. Also purified like -Carotene. [Beilstein 1 III 1076, 1 IV 1165.]


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