Talc CAS:14807-96-6 Basic information
|Product Categories:||Inorganics;Hydrous magnesium silicate|
Talc CAS:14807-96-6 Chemical Properties
|Melting point:||800 °C|
|Water Solubility:||Insoluble in water, cold acids, alkalies.|
|solubility:||Practically insoluble in water, in ethanol (96 per cent) and in dilute solutions of acids and alkali hydroxides.|
|EPA Substance Registry System:||Talc (14807-96-6)|
Name of commodity
Results Of Inspection
(Property】: Odorless, insipid, no sand grain , malactic feeling
Physical and chemical reactions: display positive reaction Physical and chemical reactions: display positive reaction
Acidity & Alkalinity: Neutral reaction Neutral reaction Water-Soluble Substance : ≤0.10
Acid-Soluble Substance :≤2.0
Loss On Ignition :
Arsenic Salt: ≤0.0002 <0.0002
Content Determination: 17.0%-19.5% (Magnesium Computation)
Total Bacteria per Gram: ≤1000 CFU/g 30CFU/g
Total Mould per Gram ： ≤lOOCFU/g 20CFU/g
Colibacillus: Can Not Be Detected Undetected
P. Aeruginosa: Can Not Be Detected Undetected
Staphylococcus: Can Not Be Detected Undetected
Expiry Date:AUG. 22, 2021
|Talc Usage And Synthesis|
|Chemical Properties||White to almost white micro fine powder, greasy to|
|Chemical Properties||Talc is a very fine, white to grayish-white, odorless, impalpable, unctuous, crystalline powder. It adheres readily to the skin and is soft to the touch and free from grittiness.|
|Occurrence||Talc is formed under hydrothermal conditions and is a typical mineral of weaker regional metamorphism (regional dynamo-thermometamorphism). It often occurs in association with chlorite, serpentine, or magnesite. The main parent rocks that undergo metamorphic mineral reactions leading to talc formation are either ( magnesite-bearing) siliceous dolomites, or olivine- and/or pyroxene- containing ultrabasics. In ultrabasic rocks, talc is often a product of hydrothermal alteration (autometasomatism). In commercially important deposits, talc occurs in association with tremolite, calcite, quartz, and dolomite, as the product of a more intense regional metamorphism of siliceous dolomites, and with forsterite and anthophyllite due to intense regional metamorphic overprint of ultrabasics. However, talc can also be observed as an authigenic new formation, e.g., in sandy sediments and salt deposits. Other minerals that occur in association with talc include chlorites, mica, actinolite, feldspars, rutile, pyrrhotite, pyrite, magnetite, and hematite. Limonite, a product of the weathering of iron- containing minerals, especially iron- containing ore minerals, can often be found interspersed with talc.|
|History||Talc, soapstone, and steatite have been used by humans as raw materials since prehistoric times. Molds carved from soapstone were used in the Bronze Age and early Iron Age for casting weapons and tools. In the Mediterranean cultures of the classical period, stone carvings were made from soapstone, and talc was used for treating wounds and in the production of cosmetic powder. In ancient Rome, women used large amounts of powder and rouge. The properties of talc, especially its characteristic greasy feel, were described by Pliny the Elder. The old Arabic word talq, which indicates its greasy nature, gave its name to the mineral. In 1550, Catherin de Medici made it once again fashionable to use facial makeup in the form of powdered talc colored by the addition of pigments, a fashion that found innumerable imitators and has continued without interruption until today.|
|Uses||Talc is a mineral composed of hydrated magnesium silicate with the chemical formula H2Mg3(SiO3)4 or Mg3Si4O10(OH)2. Talc is used in many industries such as paper making, plastic, paint and coatings, rubber, food, electric cable, pharmaceuticals, cosmetics|
|Uses||Dusting powder, either alone or with starch or boric acid, for medicinal and toilet Preparations; excipient and filler for pills, tablets and for dusting tablet molds; clarifying liquids by filtration. As pigment in paints, varnishes, rubber; filler for paper, rubber, soap; in fireproof and cold-water paints for wood, metal and stone; lubricating molds and machinery; glove and shoe powder; electric and heat insulator.|
|Uses||talc adds softness and sliding ability to a cosmetic formulation. It is also used as a bulking and opacifying agent, and as an absorbent in makeup preparations. Talc is an inert powder, generally made from finely ground magnesium silicate, a mineral.|
|Production Methods||Talc is a naturally occurring hydropolysilicate mineral found in many parts of the world including Australia, China, Italy, India, France, and the USA.|
The purity of talc varies depending on the country of origin. For example, Italian types are reported to contain calcium silicate as the contaminant; Indian types contain aluminum and iron oxides; French types contain aluminum oxide; and American types contain calcium carbonate (California), iron oxide (Montana), aluminum and iron oxides (North Carolina), or aluminum oxide (Alabama).
Naturally occurring talc is mined and pulverized before being subjected to flotation processes to remove various impurities such as asbestos (tremolite); carbon; dolomite; iron oxide; and various other magnesium and carbonate minerals. Following this process, the talc is finely powdered, treated with dilute hydrochloric acid, washed with water, and then dried. The processing variables of agglomerated talc strongly influence its physical characteristics.
|General Description||Odorless white to grayish-white very fine crystalline powder (unctuous). Readily adheres to the skin. Nonflammable, noncombustible, and nontoxic.|
|Air & Water Reactions||Insoluble in water.|
|Reactivity Profile||Talc has low reactivity.|
|Health Hazard||Pure talc is toxicologically harmless. However, where there are high concentrations of dust in the air, face masks should be worn. If the talc contains detectable amounts of asbestos or asbestos minerals, an MAK value of 2.0 mg/m3 applies. Talc is a nontoxic, inert substance or raw material, but it can contaminate wounds and if inhaled it can cause lung irritations.|
|Fire Hazard||Literature sources indicate that Talc is nonflammable.|
|Pharmaceutical Applications||Talc was once widely used in oral solid dosage formulations as a lubricant and diluent, although today it is less commonly used. However, it is widely used as a dissolution retardant in the development of controlled-release products. Talc is also used as a lubricant in tablet formulations; in a novel powder coating for extended-release pellets; and as an adsorbant.|
In topical preparations, talc is used as a dusting powder, although it should not be used to dust surgical gloves. Talc is a natural material; it may therefore frequently contain microorganisms and should be sterilized when used as a dusting powder.
Talc is additionally used to clarify liquids and is also used in cosmetics and food products, mainly for its lubricant properties.
|Safety Profile||The talc with less than 1 percent asbestos is regarded as a nuisance dust. Talc with greater percentage of asbestos may be a human carcinogen. A human skin irritant. Prolonged or repeated exposure can produce a form of pulmonary fibrosis (talc pneumoconiosis) which may be due to asbestos content. Questionable carcinogen with experimental tumorigenic data. A common air contaminant.|
|Safety||Talc is used mainly in tablet and capsule formulations. Talc is not absorbed systemically following oral ingestion and is therefore regarded as an essentially nontoxic material. However, intranasal or intravenous abuse of products containing talc can cause granulomas in body tissues, particularly the lungs. Contamination of wounds or body cavities with talc may also cause granulomas; therefore, it should not be used to dust surgical gloves. Inhalation of talc causes irritation and may cause severe respiratory distress in infants.|
Although talc has been extensively investigated for its carcinogenic potential, and it has been suggested that there is an increased risk of ovarian cancer in women using talc, the evidence is inconclusive. However, talc contaminated with asbestos has been proved to be carcinogenic in humans, and asbestos-free grades should therefore be used in pharmaceutical products.
Also, long-term toxic effects of talc contaminated with large quantities of hexachlorophene caused serious irreversible neurotoxicity in infants accidentally exposed to the substance.
|Carcinogenicity||In vitro assay of a number of respirable talc specimens of high purity demonstrated a modest but consistent cytotoxicity to macrophages; the investigators conclude that the talcs would be expected to be slightly fibrogenic in vivo.|
|storage||Talc is a stable material and may be sterilized by heating at 160°C for not less than 1 hour. It may also be sterilized by exposure to ethylene oxide or gamma irradiation.|
Talc should be stored in a well-closed container in a cool, dry place.
|Incompatibilities||Incompatible with quaternary ammonium compounds.|
|Regulatory Status||Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (buccal tablets; oral capsules and tablets; rectal and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.|