Phenylephrine hydrochloride CAS:61-76-7

  • Product Name:Phenylephrine hydrochloride
  • CAS:61-76-7
  • Molecular formula:C9H14ClNO2
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Phenylephrine hydrochloride CAS:61-76-7

Phenylephrine hydrochloride CAS:61-76-7 Basic information

Product Name: Phenylephrine hydrochloride
Synonyms: Benzenemethanol, 3-hydroxy-α-[(methylamino)methyl]-, hydrochloride (1:1), (αR)-;(R)-(-)-PHENYLEPHRINE HYDROCHLORIDE;(R)-PHENYLEPHRINE HYDROCHLORIDE;(R)-(-)-1-(3-HYDROXYPHENYL)-2-METHYLAMINOETHANOL HYDROCHLORIDE;(R)-(-)-3-HYDROXY-ALPHA-(METHYLAMINOMETHYL)B
CAS: 61-76-7
MF: C9H14ClNO2
MW: 203.67
EINECS: 200-517-3
Product Categories: Adrenergic Agents;pharmaceutical raw material;Pharmaceutical intermediates;Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;API;AFRIN
Mol File: 61-76-7.mol

Phenylephrine hydrochloride CAS:61-76-7 Chemical Properties

Melting point: 143-145 °C(lit.)
form: Crystalline Powder
storage temp.: Desiccate at RT
Water Solubility: >=10 g/100 mL at 21 ºC
refractive index: -45.5 ° (C=1, H2O)
pka: pK1 8.77; pK2 9.84(at 25℃)
BRN: 4158948
solubility: Freely soluble in water and in ethanol (96 per cent).
Merck: 14,7286
PH: -47 º (c=2, H2O)
alpha: -47 º (c=2, H2O)
CAS DataBase Reference: 61-76-7(CAS DataBase Reference)
EPA Substance Registry System: Phenylephrine hydrochloride (61-76-7)

Test Items

Specification

Results

Characteristic

White or almost white, crystalline powder

White crystalline powder

Identification A Identification B

 

Identification C

Positive identification(infrared absorption)

Complies

Positive identification(chloride 191)

Complies

Positive identification(The RT of the major peak of the Sample solution corresponds to that of the Standard solution)

 

Complies

Melting point

140 to 145

141.9 143.0

Specific Rotation

-43   to -47

-46.8°


Norphenylephrine0.10%

Not detected Not detected Not detected Not detected 0.03%

0.06%


Impurity C0.1%

Organic Impurities

Impurity D0.10%

Impurity E0.1%


Individual unspecified impurity 0.10 %


Total impurities 0.2%

Sulfates

Not more than0.20%

Complies

Loss on Drying

Not more than 1.0 %

0.02%

Residue on Ignition

Not more than 0.2 %

0.03%

Assay(on dried Basis)

98.0% to 102.0 %

101.0%

Particle Size

98% past 40 Mesh

98.5%

 

Residual Solvents

Methanol ≤3000 ppm

30ppm

2-Propanol 5000 ppm

200 ppm

Ethanol 5000 ppm

50ppm

 

Package and Storage

Preserve in tight and light-resistant containers.

Store at 25. Excursion permitted between 15 to 30

Conclusion

The product meets the requirements of USP39


Usesα-Adrenergic agonist. Mydriatic; decongestant.
UsesDECONGESTANTS
DefinitionChEBI: A hydrochloride that is the monohydrochloride salt of phenylephrine.


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