Lupeol CAS:545-47-1

  • Product Name:Lupeol
  • CAS:545-47-1
  • Molecular formula:C30H50O
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Lupeol CAS:545-47-1

Lupeol CAS:545-47-1 Basic information

Product Name: Lupeol
Synonyms: Lup-20(29)-en-3-ol;Lup-20(29)-en-3-ol, (3beta)-;Lupenol;Monogynol B;monogynolb;Triterpene lupeol;LUPEOL;FAGARASTEROL
CAS: 545-47-1
MF: C30H50O
MW: 426.72
EINECS: 208-889-9
Product Categories: Tri-Terpenoids;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
Mol File: 545-47-1.mol

Lupeol CAS:545-47-1 Chemical Properties

density: 0.9457
Melting point: 215°
Boiling point: 482.1°C (rough estimate)
form: neat
storage temp.: 2-8°C
refractive index: 1.4910 (estimate)
pka: 15.19±0.70(Predicted)
InChIKey: MQYXUWHLBZFQQO-QGTGJCAVSA-N
NIST Chemistry Reference: Lupeol(545-47-1)
PH: D20 +27.2° (c = 4.8 in chloroform)
alpha: D20 +27.2° (c = 4.8 in chloroform)
CAS DataBase Reference: 545-47-1(CAS DataBase Reference)

项目Item

指标 Standard

结果 Result

指标成分含量

AssayHPLC

羽扇豆醇Lupeol≥8%

8.5%

外观Appearance

灰色粉末 Gray powder

符合 conforms

物理特性



颗粒大小 Particle size

NLT100% 80

符合 conforms

失重 Loss on drying

≤2.0%

1.67%

重金属 Heavy metal



总金属 Metals

≤10.0ppm

符合 conforms

 Pb

≤2.0ppm

符合 conforms

 Hg

≤1.0ppm

符合 conforms

Cd

≤0.5ppm

符合 conforms

微生物Microorganism



细菌总数Total bacteria

≤1000cfu/g

符合 conforms

酵母菌 Yeast

≤100cfu/g

符合 conforms

大肠杆菌 Escherichia coli


不含 N/D

沙门氏菌 salmonella


不含 N/D

葡萄球菌staphylococcus


不含 N/D

结论 Conclusion

合格 Qualified

检测


批准



Lupeol Usage And Synthesis
DescriptionLupeol is a kind of novel anti-inflammatory and anti-cancer dietary triterpene that can be found in white cabbage, green pepper, strawberry, olive, mangoes and grapes. In recent years, much progress has been made on the application of this molecule for clinical treatment of various kind of disorders. On the one hand, it has been extensively studied that it is capable of inhibiting inflammation under both in vitro and in animal models. Studies have shown that Lupeol is a multi-target agent during its anti-inflammation effect, targeting on many key molecular pathways involving nuclear factor kappa B (NFκB), cFLIP, Fas, Kras, phosphatidylinositol-3-kinase (PI3K)/Akt and Wnt/β-catenin. On the other hand, Lupeol has strong anti-tumor effect during treatment of various cancer types such as prostate, skin, pancreatic and breast cancer. The anti-tumor effect might be related to its potential to modulate important signaling pathways such as nuclear factor kappa B (NFκB) and the phosphatidylinositol 3-kinase [PI3K] /Akt (protein kinase B pathway), which are crucial during tumorigenesis.
Referenceshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764818/
https://en.wikipedia.org/wiki/Lupeol
Chemical PropertiesWhite powder
Usesantineoplastic
UsesAbundant plant triterpene. Occurs in the skin of lupin seeds, in circle, in the latex of fig trees and of rubber plants. It was detected in cocoons of Bombyx mori.
DefinitionChEBI: A pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in m ny edible fruits and vegetables.


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