Scopolamine hydrobromide CAS:114-49-8

  • Product Name:Scopolamine hydrobromide
  • CAS:114-49-8
  • Molecular formula:C17H22BrNO4
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Scopolamine hydrobromide CAS:114-49-8

Scopolamine hydrobromide CAS:114-49-8 Basic information

Product Name: Scopolamine hydrobromide
Synonyms: (1R,2S,4R,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0²;5-alpha-h-tropan-3-alpha-ol,6-beta,7-beta-epoxy-1-alpha-(-)-tropate(ester;alpha-(hydroxymethyl)-benzeneaceticaci9-methyl-3-oxa-9-azatricyclo[3.3.1.;beldavrin;euscopol;hydroscinehydrobromide;hyocinefhydro
CAS: 114-49-8
MF: C17H22BrNO4
MW: 384.26
EINECS: 204-050-6
Product Categories: Isotope Labeled Compounds;Acetylcholine receptor;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;API;chemical reagent;pharmaceutical intermediate;Alkaloids;Aromatics;Heterocycles;Intermediates &
Mol File: 114-49-8.mol

Scopolamine hydrobromide CAS:114-49-8 Chemical Properties

Melting point: 195-199 °C (dry matter)(lit.)
form: powder
storage temp.: Store at RT
solubility: H2O: 50 mg/mL
PH: D25 -24 to -26° (c = 5, calculated on anhydrous basis)
alpha: D25 -24 to -26° (c = 5, calculated on anhydrous basis)
CAS DataBase Reference: 114-49-8(CAS DataBase Reference)
EPA Substance Registry System: Scopolamine hydrobromide (114-49-8)

TEST ITEMS

检测项

SPECIFICATION

TEST RESULT

检测结

Appearance

外观

White or almost white powder

白色或类白色粉末

White power

白色粉末

 

Solubility

溶解度

 

Freely soluble in water, soluble in ethanol(96%) and practically insoluble in ether

易溶于水,溶于96%的乙醇,理论上不溶于乙醚

 

Complies

符合

 

Identification

鉴别

 

IR: The infra-red absorption spectrum is concordant with the spectrum obtained from scopolamine hydrobromide WS. 红外

 

Complies

符合

Specific Optical Rotation

比旋度

 

-24° -26°

-2501

Melting Point  熔点

Report

195.

PH-5% solution  (PH)

40-55

445

Loss on drying(5.0g)干燥失重

130max

11.27

Sulphated ash(1.0g) 灰分

01max

0.01

Assay 含量

985%~102%

99.91%

Conclusion结论

It complies as per the above specifications.符合

备注:(1本产品要在低温(-10℃以下冷冻储藏)、干燥、密封的条件下贮藏

          The products should be stored in the conditions of low temperature

( below 10 ℃ cold storage), drying and sealing 

2)本产品易吸水,不能长时间暴露在空气当中

        The product is easy moisture absorption and can't be exposed in the air for long time.

Scopolamine hydrobromide Usage And Synthesis
Chemical PropertiesOff-White Solid
UsesAn acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant
DefinitionChEBI: A hydrobromide that is obtained by reaction of scopolamine with hydrogen bromide.
Brand nameIsopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).
General DescriptionScopolamine hydrobromide(hyoscine hydrobromide) occurs as white orcolorless crystals or as a white, granular powder. It is odorlessand tends to effloresce in dry air. It is freely soluble inwater (1:1.5), soluble in alcohol (1:20), only slightly solublein chloroform, and insoluble in ether.
Scopolamine is a competitive blocking agent of theparasympathetic nervous system as is atropine, but it differsmarkedly from atropine in its action on the higher nervecenters. Both drugs readily cross the blood-brain barrierand, even at therapeutic doses, cause confusion, particularlyin the elderly.
General DescriptionColorless crystals or white powder or solid. Has no odor. pH (of 5% solution): 4-5.5. Slightly efflorescent in dry air. Bitter, acrid taste.
Air & Water ReactionsSensitive to air, light and moisture. Water soluble.
Reactivity ProfileScopolamine hydrobromide is incompatible with acids, bases and oxidizing agents. .
Fire HazardFlash point data for Scopolamine hydrobromide are not available; however, Scopolamine hydrobromide is probably combustible.
Biological ActivityNon-selective muscarinic antagonist. Widely used clinically to treat motion sickness.
Clinical UseA sufficiently large dose of scopolamine will cause an individualto sink into a restful, dreamless sleep for about8 hours, followed by a period of approximately the samelength in which the patient is in a semiconscious state.During this time, the patient does not remember events thattake place. When scopolamine is administered with morphine,this temporary amnesia is termed twilight sleep.
Purification MethodsThe hydrobromide is recrystallised from Me2CO, H2O or EtOH/Et2O and dried. It is soluble in H2O (60%) and EtOH (5%) but insoluble in Et2O and slightly in CHCl3. The hydrochloride has m 300o (from Me2CO). The free base is a viscous liquid which forms a crystalline hydrate with m 59o and [] D 20 -28o (c 2.7, H2O). It hydrolyses in dilute acid or base. [Meinwald J Chem Soc 712 1953, Fodor Tetrahedron 1 86 1957, Beilstein 6 III 4185.]


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