Cyclooctapentylose CAS:17465-86-0 Basic information
|Synonyms:||Sugammadex Sodium Impurity 34;gamma-CD;gammadex;GCD;SCHARDINGER GAMMA-DEXTRIN;CYCLOFLO(TM) 42;CYCLOOCTAOSE;CYCLOOCTAAMYLOSE|
|Product Categories:||Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Dextrins、Sugar & Carbohydrates;Alcohols;Building Blocks;C11 to C30+;C20 to C60+;Chemical Synthesis;Ethers;Organic Building Blocks;Oxygen Compoun|
Cyclooctapentylose CAS:17465-86-0 Chemical Properties
|density:||1.2064 (rough estimate)|
|Melting point:||≥300 °C|
|Boiling point:||845.2°C (rough estimate)|
|Water Solubility:||232g/L(25 ºC)|
|refractive index:||1.7500 (estimate)|
|solubility:||1 M NaOH: 25 mg/mL, may be clear to slightly hazy|
|PH:||[α]D25 +174～+179° (c=1, H2O) (After Drying)|
|alpha:||[α]D25 +174～+179° (c=1, H2O) (After Drying)|
|λmax:||λ: 420 nm Amax: ≤0.20|
|optical activity:||[α]20/D +13.5±0.5°, c = 10% in H2O|
|EPA Substance Registry System:||.gamma.-Cyclodextrin (17465-86-0)|
White or almost white, amorphous or crystalline powder Freely soluble in water and in propyleneglycol, very slightly soluble in alcohol
Same absorption bands as USP Gamma Cyclodextrin RS
The retention time of the major peak of sample solution corresponds to the standard solution
Residue on Ignition
Sum of Other Impurities
Loss on Drying
Color and Clarity of Solution
At 420 nm, the absorbance is not greater than 0.20, and the solution is clear
The total aerobic microbial count
The total combined moulds and yeasts count
Packaging and storage
Preserve in well-closed containers. Store at room temperature
Conform to USP41-NF36
|Cyclooctapentylose Usage And Synthesis|
|Chemical Properties||White powder or crystal|
|Chemical Properties||Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.|
|Production Methods||Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.|
|Pharmaceutical Applications||Cyclodextrins are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex.|
Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.
Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material. γ-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules;it has low toxicity and enhanced water solubility.
In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent.
In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation.
Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.