Cyclooctapentylose CAS:17465-86-0

  • Product Name:Cyclooctapentylose
  • CAS:17465-86-0
  • Molecular formula:C48H80O40
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Cyclooctapentylose CAS:17465-86-0

Cyclooctapentylose CAS:17465-86-0 Basic information

Product Name: Cyclooctapentylose
Synonyms: Sugammadex Sodium Impurity 34;gamma-CD;gammadex;GCD;SCHARDINGER GAMMA-DEXTRIN;CYCLOFLO(TM) 42;CYCLOOCTAOSE;CYCLOOCTAAMYLOSE
CAS: 17465-86-0
MF: C48H80O40
MW: 1297.12
EINECS: 241-482-4
Product Categories: Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Dextrins、Sugar & Carbohydrates;Alcohols;Building Blocks;C11 to C30+;C20 to C60+;Chemical Synthesis;Ethers;Organic Building Blocks;Oxygen Compoun
Mol File: 17465-86-0.mol

Cyclooctapentylose CAS:17465-86-0 Chemical Properties

density: 1.2064 (rough estimate)
Melting point: ≥300 °C
Boiling point: 845.2°C (rough estimate)
form: powder
Water Solubility: 232g/L(25 ºC)
refractive index: 1.7500 (estimate)
pka: 11.68±0.70(Predicted)
BRN: 5725162
InChIKey: GDSRMADSINPKSL-HSEONFRVSA-N
solubility: 1 M NaOH: 25 mg/mL, may be clear to slightly hazy
Merck: 14,2718
PH: [α]D25 +174~+179° (c=1, H2O) (After Drying)
alpha: [α]D25 +174~+179° (c=1, H2O) (After Drying)
λmax: λ: 420 nm Amax: ≤0.20
optical activity: [α]20/D +13.5±0.5°, c = 10% in H2O
EPA Substance Registry System: .gamma.-Cyclodextrin (17465-86-0)

Product Name

Cyclooctapentylose

CAS

17465-86-0

MF

C48H80O40

MW

1297.12

Weight

280kg

Batch No


Items tested

Specifications

Results

Appearance

White or almost white, amorphous or crystalline powder Freely soluble in water and in propyleneglycol, very slightly soluble in alcohol

Conform

Identification

 IR:

Same absorption bands as USP Gamma Cyclodextrin RS

Conform

HPLC:

The retention time of the major peak of sample solution corresponds to the standard solution

Conform

Optical rotation:

+174°-+180°

+174°

Assay  

98.0%-102.0%

99.5%

Residue on Ignition

 0.1%

0.05%

Reducing Substances

0.5%

0.1%

Alpha cyclodextrin

0.5%

0.04%

Betadex cyclodextrin

0.5%

0.04%

Sum of Other Impurities

0.5%

0.08%

Loss on Drying

11.0%

8.9%

Color and Clarity of Solution

At 420 nm, the absorbance is not greater than 0.20, and the solution is clear

Conform

The total aerobic microbial count

1000cfu/g

<10cfu/g

The total combined moulds and yeasts count

100cfu/g

<10cfu/g

Packaging and storage

Preserve in well-closed containers. Store at room temperature

Conclusion

Conform to USP41-NF36

Cyclooctapentylose Usage And Synthesis
Chemical PropertiesWhite powder or crystal
Chemical PropertiesCyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.
Production MethodsCyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.
Pharmaceutical ApplicationsCyclodextrins are ‘bucketlike’ or ‘conelike’ toroid molecules, with a rigid structure and a central cavity, the size of which varies according to the cyclodextrin type. The internal surface of the cavity is hydrophobic and the outside of the torus is hydrophilic; this is due to the arrangement of hydroxyl groups within the molecule. This arrangement permits the cyclodextrin to accommodate a guest molecule within the cavity, forming an inclusion complex.
Cyclodextrins may be used to form inclusion complexes with a variety of drug molecules, resulting primarily in improvements to dissolution and bioavailability owing to enhanced solubility and improved chemical and physical stability.
Cyclodextrin inclusion complexes have also been used to mask the unpleasant taste of active materials and to convert a liquid substance into a solid material. γ-cyclodextrin has the largest cavity and can be used to form inclusion complexes with large molecules;it has low toxicity and enhanced water solubility.
In parenteral formulations, cyclodextrins have been used to produce stable and soluble preparations of drugs that would otherwise have been formulated using a nonaqueous solvent.
In eye drop formulations, cyclodextrins form water-soluble complexes with lipophilic drugs such as corticosteroids. They have been shown to increase the water solubility of the drug; to enhance drug absorption into the eye; to improve aqueous stability; and to reduce local irritation.
Cyclodextrins have also been used in the formulation of solutions,suppositories, and cosmetics.


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