2-Hydroxypropyl-β-cyclodextrin CAS:128446-35-5

  • Product Name:2-Hydroxypropyl-β-cyclodextrin
  • CAS:128446-35-5
  • Molecular formula:C63H112O42
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2-Hydroxypropyl-β-cyclodextrin CAS:128446-35-5

2-Hydroxypropyl-β-cyclodextrin CAS:128446-35-5 Basic information

Product Name: 2-Hydroxypropyl-β-cyclodextrin
Synonyms: Hydroxypropyl beta cyclodextrin aqueous solution;Injection grade hydroxypropyl betadex;Pharmaceutical grade hydroxypropyl betadex;Technical grade hydroxypropyl beta cyclodextrin;HPBCD/(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN;beta-hydroxypropylcyclodextrin;(2-H
CAS: 128446-35-5
MF: C63H112O42
MW: 1541.54
EINECS: 420-920-1
Product Categories: Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Chelation/Complexation Compounds;Synthetic Reagents;CyclodextrinsCell Culture;CyclodextrinsSynthetic Reagents;Cell Signaling and Neuroscien
Mol File: 128446-35-5.mol

2-Hydroxypropyl-β-cyclodextrin CAS:128446-35-5 Chemical Properties

Melting point: 278 °C (dec.)
form: solution (clear, colorless)
storage temp.: 2-8°C
Water Solubility: Soluble in water.
refractive index: 125 ° (C=1, H2O)
solubility: H2O: 45 % (w/v)
optical activity: [α]20/D 10.5±1°, neat
EPA Substance Registry System: .beta.-Cyclodextrin, 2-hydroxypropyl ethers (128446-35-5)

Test Standard





Molar Substitution



Clarity of solution

50%(w/v) water solution is clear



same absorption bands as USP

Hydroxypropyl Betadex RS


Loss on Drying





10%(w/v) water solution




Propylene oxide



Propylene glycol



Sum of Other Impurities






Any other single impurity



Heavy Metal





60 cfu/g




Bacterial endotoxins




Packaging and storage

Preserve in well-closed containers. store at room temperature .

2-Hydroxypropyl-β-cyclodextrin Usage And Synthesis
Chemical PropertiesWhite to slightly yellow powder
Chemical PropertiesHydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.
Uses2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.
Usesenteric coating, sustained release formulations, buccal and transdermal drug delivery
Uses2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis
Production MethodsHydroxypropyl betadex is prepared by the treatment of an alkaline solution of b-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.
Pharmaceutical ApplicationsHydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations.
Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.
SafetyThe pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability.
storageStore in well-closed containers.
Regulatory StatusIncluded in oral and parenteral medicinal products. Included in an injectable preparation licensed in the UK for intramuscular or intravenous administration.

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