Scopolamine butylbromide CAS:149-64-4

  • Product Name:Scopolamine butylbromide
  • CAS:149-64-4
  • Molecular formula:C21H30BrNO4
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Scopolamine butylbromide CAS:149-64-4

Scopolamine butylbromide CAS:149-64-4 Basic information

Product Name: Scopolamine butylbromide
Synonyms: (1S,2R,4S;BUTYLMIN;HYOSCINE BUTYLBROMIDE;HYOSCINE N-BUTYL BROMIDE;SCOPOLAMINI BUTYLBROMIDUM;(-)-SCOPOLAMINE N-BUTYL BROMIDE;SCOPOLAMINE N-BUTYL BROMIDE;(-)-N-BUTYLSCOPOLAMIDE BROMIDE
CAS: 149-64-4
MF: C21H30BrNO4
MW: 440.37
EINECS: 205-744-1
Product Categories: Miscellaneous;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File: 149-64-4.mol

Scopolamine butylbromide CAS:149-64-4 Chemical Properties

Melting point: 142-1440C
form: powder
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: H2O: 50 mg/mL
PH: D20 -20.8° (c = 3 in water)
alpha: D20 -20.8° (c = 3 in water)
optical activity: [α]20/D 39°, neat
CAS DataBase Reference: 149-64-4(CAS DataBase Reference)

TESTS

SPECIFICATION

RESULT

Description

外观

A white or almost white crystalline powder

白色或类白色粉末

Complies

Solubility

溶解度

Freely soluble in water and methylene chloride; sparingly soluble in ethanol

易溶于水,二氯甲烷,微溶于乙醇

Complies

Identification 鉴别

 

A) Should be -18.000 to  20.000

 

 

 19.000

A) By specific optical rotation 旋光

B) By Melting Point 熔点

B) Should be  139.00C -141.00C

140.90C

C) By IR Spectroscopy

红外

C) The I.R Spectrum of the sample must be concordant with that of Reference Standard

/ Working Standard

Complies

D) By chemical Test as per B.P

D) A violet color should develop

Complies

E) By chemical Test as per B.P

E) No precipitate should form

Complies

F) By test of Bromides

F) Should be positive

Complies

Appearance of Solution

Should be clear and colorless

Complies

pH Value

Should be 5.50 to 6.50

6.25

Specific Optical Rotation 比旋度

Should be -18.00º to -20.00º

 19.000

Loss on Drying 干燥失重

NMT 2.50 % w/w

0.14%

Sulphated Ash 灰分

NMT 0.10 % w/w

0.04%

Assay (By Silver Nitrate Titration)

含量

NLT 98.00 % & NMT 101.00%

Calculated on dry basis

99.27% - Complies

备注: 1)本产品要在低温(-10℃以下冷冻储藏)、干燥、密封的条件下贮藏

The products should be  stored in  the  conditions of  low temperature     ( below 10 ℃ cold storage), drying and sealing

2)本产品易吸水,不能长时间暴露在空气当中

The product is easy moisture absorption and can't be exposed in the air for long time.

Scopolamine butylbromide Usage And Synthesis
Chemical PropertiesCrystalline Solid
OriginatorButylscopolamine,China Pharm
UsesAnticholinergic. Antispasmodic
Manufacturing Process1300 g of scopolamine base and 350 g of n-butylbromide in 600 ml acetonitrile is heated at 65°C for 160 hours. The oil obtained is dissolved in methanol. The solution is cooled and crystalline scopolamine N-n-butylbromide is filtered. After recrystallization from methanol was obtained scopolamine N-n-butylbromide with melting point 142-144°C and [α]d 20 = -20.5° (3% solution in water); yield 65%.
Therapeutic FunctionAnticholinergic, Spasmolytic, Antitussive


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