Cyanamide CAS:420-04-2 Basic information
|Synonyms:||hydrogencyanamid;N-Cyanoamine;tsaks;USAF ek-1995;usafek-1995;CARBODIIMIDE;CYANAMIDE F1000;CYANAMIDE L500|
|Product Categories:||Pyridazines;Halogenated Heterocycles ,Quinazolines;Pharmaceutical Intermediates;Inorganics;C1 to C5;Cyanides/Nitriles;Nitrogen Compounds|
Cyanamide CAS:420-04-2 Chemical Properties
|Melting point:||45-46 °C(lit.)|
|Boiling point:||83 °C0.5 mm Hg(lit.)|
|Water Solubility:||775 g/L|
|solubility:||ethanol: soluble10%, clear to hazy, colorless to faintly yellow|
|NIST Chemistry Reference:||Cyanamide(420-04-2)|
|Stability:||Unstable - heat sensitive. Incompatible with strong oxidizing agents, strong reducing agents, bases, acids, iron and its salts, steel, brass, lead, moisture. Reacts with acids to produce very toxic gas.|
|CAS DataBase Reference:||420-04-2(CAS DataBase Reference)|
|EPA Substance Registry System:||Cyanamide (420-04-2)|
检测项目 质量标准 检测结果
Test Items Specification Test Results
外观 无色透明液体 符合
Appearance Colorless clear liquid Conforms
含量 Assay 50% Min. 50.5%
pH 值pH Value 3.5-5.4 5.0
双氮胺 Dicyandiamide 0.5%Max 0.45%
硫脉 Thiourea 0.1%Max 符合 Conforms
钙 Calcium (Ca) 100mg/L Max. 符合 Conforms
铁 Ferrum (Fe) 40mg/L Max. 符合 Conforms
汞 Mercury (Hg) 0.05mg/L Max. 符合 Conforms
铅 Lead (Pb) 1.0mg/L Max. 符合 Conforms
结论 Conclusion 符合质量标准 Conforms to the specification
|Cyanamide Usage And Synthesis|
|Physicochemical property||Cyanamide is also called hydrogen cyanamide，urine anhydride, its scientific name is amino nitrile. It is white orthogonal series crystals, in a diamond shaped, colorless, easy moisture. Melting point is 42℃, boiling point is 83℃ (50.66kPa), vapor pressure is (20℃) is 500MPa. Cyanamide is high solubility in water and weak acid, and completely miscible in water of 43℃. It is soluble in benzene and phenol, alcohols, amines, ethers, ketones, slightly soluble in benzene, halogenated hydrocarbons, but insoluble in epoxy ethane, cyclohexane. Solubility (20℃ ): water 4.59kg/L, methyl ethyl ketone 505g/kg, acetic acid ethyl ester 424g/kg, octanol 288g/kg, chloroform 2.4 g/kg. It can volatilize with water vapor, so it can dissolve in a series of solvents. In polar organic solvent, solubility is large, and in non-polar solvents is smaller. Crystal cyanamide is not stable, large polarity. Due to the cyanamide molecular structure containing the cyano and amino, both of which are active groups, it has the functional groups of the multiple reaction performance, prone to addition, substitution, condensation reaction. It is stable to light. It decomposites to dicyandiamide and polymers in alkali, and decomposites to urea in acid. It decompose when heated to 180℃. Product has four kinds of crystal of 25%, 40%, 50% and 90%. 25% of cyanamide solution is mainly used for creatine production, 50% and 90% of cyanamide solutions are mainly used for producing methylene urea pharmaceutical intermediates.|
Figure 1 Three-dimensional structure of cyanamide
|Main application||1. Important pharmaceutical raw material|
Cyanamide is mainly used for the production of hydrochloric acid cytarabine, dye intermediate 3-amino-5-hydroxy-1,2,4-nitrogen azole, cyanide urea amine, melamine methyl carbamate, cyanide urine amide, thiourea, carbendazim. It is also raw material for preparation of organic guanidine, then the product pharmaceutical barbituric acid, sulfa drugs and guanidine salt, etc. It can also be used for production anticancer drugs of fluorouracil in medicine. Cyanamide calcium salt can be used for clinical treatment of alcoholism and anthelmintic action.
2. Raw materials for chemical pesticides
2.1 Cyanamide can be used as chemical raw materials of no residue, low toxicity, broad-spectrum pesticide, and can also be used for production of antibacterial agent such as carbendazim, benzene benomyl, methyl mepanipyrim and mepanipyrim, Pirimicarb, pyrimidinoxy phosphorus, herbicide Chlorsulfuron, Metsulfuron methyl, Metsulfuron methyl ethyl, long ether tribenuron methyl and bensulfuron methyl and pyrazole ethyl, hexazinone, etc. It has the significance of technological innovation for pesticide production, solves the environmental pollution while the general pesticide production enterprises can be difficult to solve the problem using calcium cyanamide in the production of pesticide. So using cyanamide can save equipment investment, reduce production costs.
2.2 In recent years, cyanamide is used as off leaf agents, herbicides and pesticides in abroad, but also can be used as pesticide, and cyanamide has a certain of nitrogen application effect. Cyanamide solution was used as a defoliant, non-toxic pesticides for fruit trees in abroad.
2.3 The cyanamide in agriculture can be used as plant growth regulators, with both pesticidal and bactericidal effects. Directly sprayed on crops, can effectively inhibit the activity of catalase in plants, accelerate plant oxidative pentose phosphate (PPP) circulation, thus speeding up the generation of basic substances in plants, play a role in the regulation of growth. The field efficacy trials showed that It can regulate the growth and increase production of cherries and grapes. Before 15 to 20 days in grape germination, it sprayed evenly on the branches, uniform of a drug on bud eye, can advance germination of 7 to 10 days. For early flowering, full flowering stage, coloring period and mature period, using it can aslo advance early. At the same time it is good dormancy terminating agent in the production of kiwi, cherries, grapes. it sprayed evenly on bud eye in the dormant period, it can break the dormancy period, can be early germination, early flowering, early mature and early on the market. It can significantly improve the yield, change fruit fleshy and improve the quality of varieties.
|Excellent flame retardant materials||The cyanamide is mainly used for production of flame retardant agent such as o-methyl isourea, creatine, guanidine phosphate. At the same time, as a kind of flame retardant material with excellent performance, cyanamide polyols and polyether solution are used for production of polyurethane, can significantly improve the flame retardancy of polyurethane material, which is a new type of fine chemical new materials.|
|Fixing material||The materials from the two polymer fixing agent melamine dicyandiamide can be used in the production of fixing agent Y, fixing agent G, fixing agent M and fixing agent B. Reaction product of cyanamide, poly formaldehyde and acid copper is fixing agent B, which is gray powder, can be used for direct dyes and staining after treatment. 30.9 copies of diethylenetriamine and 24.8 dicyandiamide react under 100℃, then reaction again in 155 ℃, after 5h cooling, crushing to obtain colorless powder. It is a kind of formaldehyde-free fixing agent, low cost, having a development promising as green products.|
|Toxicity||1. It has the skin irritation and corrosive, can lead to severe dermatitis, the person suction can cause mucosal irritation, transient flushing, headache, dizziness, shortness of breath, tachycardia and hypertension and other symptoms.|
2. Mutagenicity test: mild irritation to rabbit skin and eye severe stimulation, the drug of guinea pig skin allergic reaction test is attenuated sensitive drugs.
3.The effect maximum dose is 0.2mg/kg/d in rats with 90d sub chronic feeding experiment. Cyanamide drug and 50% aqueous solution are medium toxicity. Please use it to Caution!
|Chemical property||Pure cyanamide is a transparent liquid, m.p.-115℃, b.p.-8.5℃, soluble in alcohols, phenols, amines, ethers, easily soluble in benzene, alkyl halides, 77.5% of it is soluble in water of 15℃. The high concentration of cyanamide is not stable, easy polymerization, often adding stabilizer. General merchandise for 50% of cyanamide solution, n20D 1.4050, the relative density is 1.082.|
|Uses||1.Cyanamide is an important intermediate of pesticide. It can also be used for production of antibacterial agent such as carbendazim, benzene benomyl, methyl mepanipyrim and mepanipyrim, Pirimicarb, pyrimidinoxy phosphorus, herbicide Chlorsulfuron, Metsulfuron methyl, Metsulfuron methyl ethyl, long ether tribenuron methyl and bensulfuron methyl and pyrazole ethyl, hexazinone, etc.|
2. In the pharmaceutical industry, it is used as a raw material for the production of hydrochloric acid. It is also used for the production intermediates of 3-amino-5-hydroxyl-1,2,4-triazol in the dye industry. In addition, for organic synthesis and plastic raw materials, it can be used for production of cyanuric amide, dicyandiamide, cyanide methyl carbamate etc.
3.Cyanamide liquid is used for industrial raw materials, pharmaceutical intermediates, agricultural pesticides, fertilizer, plant growth regulator, food additives etc.
4. Used in the production of materials such as urine.