Imazalil CAS:35554-44-0 Basic information
| Product Name: | Imazalil |
|---|---|
| Synonyms: | rac-1-[(R*)-2-(Allyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole;Imazalil base;Imazalil 100mg [35554-44-0];Imazalil Solution, 100ppm;imazalil:1-(2-(2,4-dichloro-phenyl)-2-(2-propenyloxy)ethyl)-1h-IMIDAZOLE;(.+/-.)-1-(beta-(Allyloxy)-2,4-dichloropheneth |
| CAS: | 35554-44-0 |
| MF: | C14H14Cl2N2O |
| MW: | 297.18 |
| EINECS: | 252-615-0 |
| Product Categories: | NULL;API;CLINAFARM;FUNGICIDE |
| Mol File: | 35554-44-0.mol |
Imazalil CAS:35554-44-0 Chemical Properties
| density: | 1.348 |
|---|---|
| Melting point: | 52.7°C |
| Boiling point: | >340°C |
| form: | neat |
| Water Solubility: | 0.018 g/100 mL |
| refractive index: | 1.5680 (estimate) |
| pka: | 6.53 (weak base) |
| BRN: | 545683 |
| InChIKey: | PZBPKYOVPCNPJY-UHFFFAOYSA-N |
| NIST Chemistry Reference: | Imazalil(35554-44-0) |
| Merck: | 13,3616 |
| vapor pressure: | 1.58 x l0-4 Pa (20 °C) |
| CAS DataBase Reference: | 35554-44-0(CAS DataBase Reference) |
| EPA Substance Registry System: | Imazalil (35554-44-0) |
Product Name | Imazalil 97%TC | Test Standard | Q/YSK43-2011 | ||
Batch No. | 2020970508 | Production Date | 2020.5.15 | ||
Sample Quantity | --- | Analysis Date | 2020.5.15 | ||
Packing Size | 25kg/Fiber drum | Quantity | 1000kg | ||
Testing Item | Testing Target | Result | |||
Content | ≥97.0% | 97.2% | |||
Water | ≤0.5% | 0.28% | |||
PH | 7.0-10.0 | 7.8 | |||
Insoluble residue in acetone |
≤0.3% |
0.15% | |||
Appearance | Light yellow Solid or Powder |
Qualified | |||
Conclusion: QUALIFIED | Analyst | Checker | |||
Chen Lizhang | Hu Yvhua | ||||
| Imazalil Usage And Synthesis |
| Description | Imazalil (also known as Enilconazole) is a kind of topical mycotic agent that used for the treatment of fungi infections. It is primarily used for the treatment of fungi attracted to tubers of the crops, including Fusarium spp, Phoma spp, and Helminthosporum solani which reduces the crop quality. It can also be applied to citrus fruits. In addition, it can also be used for the treatment of Microsporum spp and Aspergillus spp infections occurring in the dogs, either as a single topic agent or being combined with oral administrated itraconazole or griseofulvin. The mechanism of action of Imazalil is through suppressing the biosynthesis pathway of ergosterol through blocking the demethylation process. |
| References | http://www.vetbook.org/wiki/dog/index.php?title=Enilconazole https://en.wikipedia.org/wiki/Enilconazole https://www.mysciencework.com/publication/show/f0382c741754e9200388abe8cf2f0133 |
| Description | |
| Uses | antifungal |
| Uses | As a disinfectant for stable and kennel equipment; experimentaly as an agricultural fungicide. |
| Uses | Imazalil is a systemic fungicide with protective and curative action. It is used for the control of a wide range of fungal diseases on fruit, vegetables and ornamentals, powdery mildew on roses and storage diseases of citrus fruit, pome fruit, bananas and seed potatoes. It is also used as a seed dressing, for control of diseases of cereals (particularly Fusarium and Helminthosporium spp.), and it is particularly active against benzimidazole-resistant strains of plant-pathogenic fungi. |
| General Description | Slightly yellow to brown solidified oil. Non-corrosive. Used as a fungicide. |
| Air & Water Reactions | Water soluble. |
| Reactivity Profile | Imazalil is an imidazole derivative. |
| Safety Profile | Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. A skin and eye irritant. When heated to decomposition it emits toxic fumes of Cland NOx. |
| Veterinary Drugs and Treatments | Although no dosage forms are currently commercially available for topical use in the USA, Enilconazole is used topically for treating dermatophytosis in small animals and horses using compounded products. A commercially available topical rinse Imaverol? (Janssen) 10% is available with canine, bovine and equine use labeling in many countries. Intranasal instillation of enilconazole after plaque debridement has also been shown useful in treating nasal aspergillosis in small animals. Use of topical enilconazole on cats with dermatophytosis is somewhat controversial as there are apparently no products with feline labeling available in Europe or Canada. There are preliminary reports of safely and successfully using enilconazole on dermatophytic cats in combination with oral itraconazole. A topical product and a poultry environmental disinfectant product (Clinafarm EC?) is available in the USA. It is technically illegal to use this product other than it is labeled; it is an EPA licensed product in the USA. |
| Metabolic pathway | Published information is available on the metabolism of imazalil in plants and soils. The principal metabolite in plants and soils is 1-[2-(2,4- dichlorophenyl)-2-hydroxyethyl]-1H-imidazole. |
| Degradation | Imazalil is very stable to hydrolysis in dilute acids and alkalis at room temperature, in the absence of light. It is also stable to light under normal storage conditions. |
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