Kinetin CAS:525-79-1 Basic information
| Product Name: | Kinetin |
|---|---|
| Synonyms: | Kinetin, for plant cell culture, ≥99.0% (HPLC);cytokinin;cytokinin(askinetin);fap;kinetin(planthormone);n-(2-furanylmethyl)-1h-purin-6-amin;N6-FURFURYLADENINE;Adenine, N-furfuryl- |
| CAS: | 525-79-1 |
| MF: | C10H9N5O |
| MW: | 215.21 |
| EINECS: | 208-382-2 |
| Product Categories: | Purine;Amines;PLANT GROWTH REGULATOR;Biochemistry;Chemical Reagents for Pharmacology Research;Cytokinins;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Plant Growth Regulators;Inhibitors;Plant Hormones;Bases & Related Reagents; |
| Mol File: | 525-79-1.mol |
Kinetin CAS:525-79-1 Chemical Properties
| density: | 1.2639 (rough estimate) |
|---|---|
| Melting point: | 269-271 °C (dec.)(lit.) |
| Boiling point: | 355.49°C (rough estimate) |
| form: | crystalline |
| storage temp.: | −20°C |
| Water Solubility: | Soluble in water (<1 mg/ml) at 25°C, Acetic acid (49.00-51.00 mg/ml), DMSO (43 mg/ml) at 25°C, ethanol (<1 mg/ml) at 25°C, 0.1 N Sodium hydroxide (1% w/v), methanol (slightly), and dilute aqueous hydrochloric acid or sodium hydroxide (freely). |
| refractive index: | 1.7610 (estimate) |
| pka: | pKa1 2.7; pKa2 9.9(at 25℃) |
| BRN: | 21703 |
| InChIKey: | QANMHLXAZMSUEX-UHFFFAOYSA-N |
| Fp: | 269-271°C |
| solubility: | H2O: soluble |
| NIST Chemistry Reference: | Kinetin(525-79-1) |
| Merck: | 14,5311 |
| CAS DataBase Reference: | 525-79-1(CAS DataBase Reference) |
| EPA Substance Registry System: | Kinetin (525-79-1) |
TEST | SPECIFICATION | RESULTS |
Appearance | White Crystals | Conform |
Purity | ≥99.0% | 99.6% |
Water Content | ≤0.5% | 0.32% |
Heavy matal content | <20ppm | passed |
Conclusion: Lot meets specification. | ||
| Kinetin Usage And Synthesis |
| Description | Kinetin (or Vivakin) was introduced as Kinerase in the US as a new ingredient for the treatment of age related photodamage of skin. This 6- furfurylaminopurine is a synthetic cytokinin, a family of plant growth factors, and was shown to be a highly potent growth factor. In vitro, it was able to delay or prevent the onset of age-related changes in skin cells without affecting cellular lifespan. In a double-blind clinical trial, Kinetin (0.005%) partially reversed the clinical signs of photodamaged skin and demonstrated a good safety profile. It could have potential in psoriasis as well as in other proliferative skin disorders. |
| Chemical Properties | White Solid |
| Originator | Senetek (UK) |
| Uses | auxin, plant growth regulator, plant cell division promotor |
| Uses | Plant growth accelerator |
| Uses | Plant growth regulator. To augment growth of microbial cultures: BE 632589 (1963 to Hoechst). |
| Uses | A cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures |
| Brand name | Kinerase |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 21, p. 1276, 1956 DOI: 10.1021/jo01117a016 |
| Purification Methods | It forms platelets from EtOH and sublimes at 220o, but is best done at lower temperatures in a good vacuum. It has been extracted from neutral aqueous solutions with Et2O. [Miller et al J Am Chem Soc 78 1375 1956, Bullock et al. J Am Chem Soc 78 3693 1956, Beilstein 26 III/IV 3586.] |
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