Piperonyl butoxide CAS:51-03-6

  • Product Name:Piperonyl butoxide
  • CAS:51-03-6
  • Molecular formula:C19H30O5
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Piperonyl butoxide CAS:51-03-6

Piperonyl butoxide CAS:51-03-6 Basic information

Product Name: Piperonyl butoxide
CAS: 51-03-6
MF: C19H30O5
MW: 338.44
EINECS: 200-076-7
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Protected Alcohols/Phenols;stabilizer;pesticides
Mol File: 51-03-6.mol

Piperonyl butoxide CAS:51-03-6 Chemical Properties

density: 1.059 g/mL at 25 °C(lit.)
Melting point: <25 °C
Boiling point: 180 °C
form: Liquid
storage temp.: 0-6°C
Water Solubility: <0.1 g/100 mL at 18 ºC
refractive index: n20/D 1.498(lit.)
BRN: 288063
Fp: >230 °F
solubility: water: slightly soluble0.0289g/L at 20.4°C
NIST Chemistry Reference: Piperonyl butoxide(51-03-6)
Merck: 14,7476
Stability: Stable. Combustible. Incompatible with oxidizing agents.
Specific Gravity: 1.060 (20/4℃)
vapor pressure: 0.02 hPa (60 °C)
CAS DataBase Reference: 51-03-6(CAS DataBase Reference)
EPA Substance Registry System: Piperonyl butoxide (51-03-6)

Product Name











Colorless to light yellow oily liquid

Assay %


Water %


Acidity %


Refractive index n20/D

1.4970 - 1.5070

Specific gravity (20°C)

1.055 - 1.065


Accords with the enterprise standard

Piperonyl butoxide Usage And Synthesis
Chemical PropertiesLight Yellow Liquid
UsesPiperonyl butoxide is used as a synergist for pyrethrins and their synthetic analogues.
UsesInsecticide synergist, especially for pyrethroids and rotenone
General DescriptionPale yellow to light brown liquid with a mild odor and a faint bitter taste.
Air & Water ReactionsInsoluble in water.
Reactivity ProfilePiperonyl butoxide can react with oxidizing materials.
Fire HazardPiperonyl butoxide is combustible.
Agricultural UsesInsecticide synergist: A U.S. EPA restricted Use Pesticide (RUP). Not listed for use in EU countries. Piperonyl butoxide is a synergist, i.e., not a pesticide itself, but enhances the properties of other chemicals. It is used with other pesticides such as pyrethrins, pyrethroids, rotenone and carbamates in food and non-food agricultural products, home and garden products, termite and mosquito products, and veterinary pesticide products. It inhibits the insect’s ability to break down an insecticide before it takes effect, thereby prolonging the action, and reduces the necessity for using a stronger formulation.
Trade nameThe U.S. EPA lists 7,340 products containing this substance, 1,622 of which are active
Safety ProfilePoison by skin contact. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Many glycol ether compounds have dangerous human reproductive effects, Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomDosition it emits PLATINOL 0 cis-PLATlNUM(II) DIAMMINE- DICHLORIDE
Metabolic pathwayPiperonyl butoxide is used primarily in admixture with pyrethrins and some of the pyrethroids to enhance and prolong their insecticidal action. Much of this use is in domestic and industrial situations. Metabolism studies were conducted soon after its discovery and first use in the 1950s and 1960s. The main impetus initially was to understand the mode of action as a synergist. When this was shown to be due to the inhibition of oxidative metabolism, further studies were conducted to address possible toxic interactions with other pesticides and drugs in man.
Piperonyl butoxide undergoes rapid photodegradation and microbial degradation in soil. It is also rapidly metabolised in insects and mammals by oxidative attack at the methylenedioxy carbon atom and in the side chain. A comprehensive review by Casida (1970) describes the chemistry, mode of action and metabolism of piperonyl butoxide and several related methylenedioxyphenyl compounds. Though published nearly 30 years ago, the review remains a very useful compilation of a large amount of information, supported by more than 300 references.
DegradationPiperonyl butoxide is stable to hydrolysis at pH 5,7 and 9 in sterile buffers in the dark at 25 °C. It is rapidly degraded in aqueous solution at pH 7 in sunlight with a DT50 of 8.4 hours (PM). The compound was found to be relatively stable under a variety of irradiation conditions as a thin film on glass or in organic solvent (methanol, benzene and cyclohexane). Loss of the butoxyethoxy side chain was observed to give 5-methyl-6-propyl-l,3- benzodioxole (2), butoxyethanol (3) and ethanediol (4) (Fishbein and Gaibel, 1970). These studies did not utilise radiolabelled compound. The partial pathways are shown in Scheme 1.

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