Urea CAS:57-13-6

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Urea CAS:57-13-6

Urea CAS:57-13-6 Basic information

Product Name: Urea
Synonyms: Analysis of pure urea;Fluorouracil EP ImpurityG;Medical urea;Food grade urea;furanyl)​;Usp grade urea crystallization;USP grade urea;Reagent grade moisturizing urea
CAS: 57-13-6
MW: 60.06
EINECS: 200-315-5
Product Categories: Enzymes;Alphabetical Listings;Stable Isotopes;U-Z;Chaotropic Agents;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;Carbonyl Compounds;Cell Biology;Chemical Synthesis;Denaturation;Organic Building Blocks;U;Ureas;Protein Electrophores
Mol File: 57-13-6.mol

Urea CAS:57-13-6 Chemical Properties

density: 1.335 g/mL at 25 °C(lit.)
Melting point: 132-135 °C(lit.)
Boiling point: 332.48°C (estimate)
form: powder
storage temp.: 2-8°C
Water Solubility: 1080 g/L (20 ºC)
refractive index: n20/D 1.40
pka: 0.10(at 25℃)
BRN: 635724
solubility: H2O: 8 M at 20 °C
NIST Chemistry Reference: Urea(57-13-6)
Merck: 14,9867
Stability: Substances to be avoided include strong oxidizing agents. Protect from moisture.
Specific Gravity: 1.335
vapor pressure: <0.1 hPa (20 °C)
λmax: λ: 260 nm Amax: 0.03λ: 280 nm Amax: 0.02
CAS DataBase Reference: 57-13-6(CAS DataBase Reference)
EPA Substance Registry System: Urea (57-13-6)

Product Name









Test Result


White crystalline

N  Assay%


Water soluble

Soluble in water

Melting point





Accords with the enterprise standard

Usesurea is incorporated into cosmetics for a variety of purposes, including moisturizing, desquamating, anti-microbial, and buffering. urea is regarded as a “true” moisturizer rather than a humectant because it attracts and retains moisture in the corneum layer. It facilitates the natural exfoliation of keratinocytes given its ability to dissolve intercellular cement in the corneum layer. Through its anti-microbial properties that inhibit the growth of micro-organisms in a product, urea can also be part of a larger preservative system. This ingredient’s buffering action is attributed to its ability to regulate the hydrolipid mantle. In addition, urea is found to enhance the penetration and absorption of other active ingredients, relieve itchiness, and help leave the skin feeling soft and supple. Anti-inflammatory, anti-septic, and deodorizing actions allow it to protect the skin’s surface against negative changes and help maintain healthy skin. Studies show that urea does not induce photoallergy, phototoxicity, or sensitization. The safest concentration of use in skin care preparations is between 2 and 8 percent. High concentrations of urea seem to be unstable when incorporated into skin care preparations and can also cause irritation. Acidic urea solutions can produce burning or stinging sensations.
UsesUsed for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.
Usesanticholelithogenic; LD50(rat) 890 mg/kg ip
UsesUrea is a physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diu retic.
Uses1) UREA, FCC is an odorless and colorless solid that is an important nitrogen-containing substance found in mammal urine.2) Urea has little or no nutritional value to monogastric mammals but Urea is used in sugar-free chewing gum to adjust the texture

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