Abamectin CAS: 71751-41-2

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Abamectin CAS: 71751-41-2

Abamectin CAS: 71751-41-2 Basic information

Abamectin CAS: 71751-41-2 Chemical Properties

Product Name:Abamectin
Synonyms:Abamectin 100mg [71751-41-2];AbaMectin (AverMectin B1)(FDA);Purity of AbaMectin;AverMectin B1a-AverMectin B1b Mixt.;ABAMECTIN 95%;Mixture of abamectin B1a and B1b;Abamectin Solution in Acetonitrile;Abamectin soL
CAS:71751-41-2
MF:C49H74O14
MW:887.11
EINECS:200-096-6
Abamectin Chemical Properties
Melting point 150-155°C
alpha D +55.7 ±2° (c = 0.87 in CHCl3)
Boiling point 717.52°C (rough estimate)
density 1.16
vapor pressure <2 x 10-7 Pa
refractive index 1.6130 (estimate)
Fp 150 °C
storage temp. 2-8°C
solubility Soluble in DMSO
form neat
Water Solubility 0.007-0.01 mg l-1 (20 °C)
Merck 13,2

Item

Standard

Results

Appearance

White to yellowish white crystalline powder

White crystal powder

Heavy Metals %

0.001%

0.001%

Residue on Ignition %

0.1%

0.08%

Loss on drying

2.0%

1.8%

External standard cont ent

92%

95.3%

Normalized content

95.0%

98.4%

Conclusion

Qualified

Abamectin Usage And Synthesis


Characteristics of avermectin series agents1. broad spectrum insecticide
The current reported insecticide spectrum of Abamectin contains 84 species. In China, it is mainly used for control of pests with small body, multiple generations and being prone to become drug-resistant such as pear psylla, and cotton aphid, leaf mining pests such as the Inter-American Blanchard, pest mites such as Tetranychus urticae, Calacarus carinatus Green, Tetranychus viennensis and pests with wide range of hosts and miscellaneous eating habits such as Plutella xylostella.
2. the unique mechanism of killing pests
Abamectin is a nerve toxic agent. Its mechanism is targeting to the GABAA receptor of insect neuron synapse or neuromuscular synapse, interfering with the information transfer of nerve endings, namely stimulating the nerve endings to release neurotransmitter inhibitor γ-aminobutyric acid (GA-BA), prompting the extensive opening of the GABA-gated chloride channel with chloride channel-activating effect. In this case, large influx of chloride ions cause nerve membrane potential being hyperpolarized, resulting in the inhibition of the nerve membrane, and thereby blocking the contact between nerve endings and muscle, thus causing insect paralysis, poor feeding, and death. Because of its unique mechanism of action, it has no cross-resistance with commonly-used agents. According to reports, in addition to GABA receptors controlled chloride channels, Abamectin can also affect other ligand-controlled chloride channels. For example, Ivermectin can induce the irreversible increase of membrane conduction of muscle fibers (non GABA innervations) of locust.
Chemical PropertiesAbamectin is a colorless to yellowish crystalline powder. It is soluble in acetone, methanol, toluene, chloroform, and ethanol, but insoluble in water. It is stable, and incompatible with strong oxidizing agents. Abamectin is a mixture of Abamectins containing about 80% Abamectin B1a and 20% Abamectin B1b. These two components, B1a and B1b, have very similar biological and toxicological properties. The Abamectins are insecticidal/miticidal compounds derived from the soil bacterium Streptomyces avermitilis. Abamectin is used to control insect and mite pests of citrus, pear, and nut tree crops, and is used by homeown- ers to control fi re ants. It acts on the nervous system of insects, causing paralyzing effects. Abamectin is a general use pesticide (GUP). It is grouped as toxicity class IV, meaning practically non-toxic, requiring no precautionary statement on its label
OriginatorAbamectin,Yellow River Enterprise Co. (a.k.a Yelori)
UsesMixture of Abamectins, containing at least 80% of Abamectin B1a (C48H72O14) and not more than 20% of Abamectin B1b (C47H70O14). Used as acaricide, insecticide
Usesectoparasiticide, CNS stimuant, mutagen
UsesAcaricide; insecticide.


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