Benfotiamine cas :22457-89-2

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Benfotiamine cas :22457-89-2

Benfotiamine cas :22457-89-2 Basic information

Product Name: Benfotiamine
CAS: 22457-89-2
MF: C19H23N4O6PS
MW: 466.45

Benfotiamine cas :22457-89-2 Chemical Properties

Tests

 

Specifications

 

Results

 

Appearance

Pale-yellow or almost white powder; odorless

 

White powder

 

Identification

IR spectra shows the similarity between sample and standard

 

Passed


The retention time of the major peak corresponds with it of the reference standard

 

Passed

 

Solution color and clearness

 

Colorless to pale-yellow clear solution

 

Passed

 

Chloride

 

NMT 0.053%

 

Passed

 

Sulfate

 

NMT 0.011%

 

Passed

 

Heavy metals

 

NMT 20 ppm

 

Passed

 

Loss on drying

 

NMT 1.50%

 

0.6%

 

Related substance

 

Benzoic acid: NMT 0.1%

 

Passed


 

Thiamine: NMT 0.1%

 

Passed


 

Total impurities: NMT 1.0%

 

Passed

 

Purity

 

≥ 98.0%

 

99.3%

 

Storage

Preserve in well-closed container  room temperature.

 

Passed

 

Conclusion

Our product is tightly evaluated on the basis of specifications according to Enterprise Standard by Quality Control Department.


Benfotiamine Usage And Synthesis
Chemical Propertiescrystals
OriginatorBiotamin,Sankyo
UsesVitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185).
DefinitionChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.
Manufacturing Process28.6 g 84% phosphoric acid was heated to temperature about 270°C. After cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was added and left at temperature 100°C before an isolation of HCl was ended. After adding of an ice water and acetone, phosphate ester of vitamin B1 was fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient temperature 7 days for a hydrolysis. Then a solution was with acetone diluted and the mixture was cooled, whereupon vitamin B1 monophosphate hydrochloride was isolated.
The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was dropwise added with stirring and cooling. The obtained mixture was neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5- 4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was precipitated. The product was suspended in water, was bringing with NaOH to pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate was prepared; MP: 165°C (with decomposition).
Therapeutic FunctionAnalgesic

Benfotiamine Preparation Products And Raw materials
Raw materialsBenzoyl chloride-->Thiamine hydrochloride-->Phosphoric acid


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