Benfotiamine cas ：22457-89-2 Basic information
Benfotiamine cas ：22457-89-2 Chemical Properties
Pale-yellow or almost white powder; odorless
IR spectra shows the similarity between sample and standard
The retention time of the major peak corresponds with it of the reference standard
Solution color and clearness
NMT 20 ppm
Loss on drying
Benzoic acid: NMT 0.1%
Thiamine: NMT 0.1%
Total impurities: NMT 1.0%
Preserve in well-closed container ＆ room temperature.
Our product is tightly evaluated on the basis of specifications according to Enterprise Standard by Quality Control Department.
|Benfotiamine Usage And Synthesis|
|Uses||Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185).|
|Definition||ChEBI: A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.|
|Manufacturing Process||28.6 g 84% phosphoric acid was heated to temperature about 270°C. After cooling to 100°C 4 g thiamine hydrochloride (vitamin B1 hydrochloride) was added and left at temperature 100°C before an isolation of HCl was ended. After adding of an ice water and acetone, phosphate ester of vitamin B1 was fallen. The precipitate was dissolved in 17 ml 1 N HCl and stood at ambient temperature 7 days for a hydrolysis. Then a solution was with acetone diluted and the mixture was cooled, whereupon vitamin B1 monophosphate hydrochloride was isolated.|
The solution of 4.3 parts vitamin B1 monophosphate hydrochloride in 16 parts of water was diluted with 11 parts 15% NaOH, 2.1 parts benzoyl chloride was dropwise added with stirring and cooling. The obtained mixture was neutralized, evaporated in vacuum, acidified with concentrated HCl to pH 3.5- 4, whereupon a crude S-derivative of vitamin B1 monophosphate ester was precipitated. The product was suspended in water, was bringing with NaOH to pH 7 and was acidified to pH 4. 3.4 g refined S-benzoylthiamine Omonophosphate was prepared; MP: 165°C (with decomposition).
|Benfotiamine Preparation Products And Raw materials|
|Raw materials||Benzoyl chloride-->Thiamine hydrochloride-->Phosphoric acid|