7-Dehydrocholesterol CAS:434-16-2

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7-Dehydrocholesterol CAS:434-16-2

7-Dehydrocholesterol CAS:434-16-2 Basic information

Product Name: 7-Dehydrocholesterol
Synonyms: (3)-7-Dehydrochlesterol;(3beta)-Cholesta-5,7-dien-3-ol;(3-beta)-cholesta-7-dien-3-ol;(3beta)-cholesta-7-dien-3-ol;3-Hydroxycholesta-5,7-diene;cholesta-5,7-dien-3-beta-ol;Cholesta-5,7-dien-3-ol;Cholesta-5,7-dien-3-ol, (3beta)-
CAS: 434-16-2
MF: C27H44O
MW: 384.64
EINECS: 207-100-5
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical Raw Materials;Steroids
Mol File: 434-16-2.mol

7-Dehydrocholesterol CAS:434-16-2 Chemical Properties

density: 0.9717 (rough estimate)
Melting point: 148-152 °C(lit.)
Boiling point: 451.27°C (rough estimate)
storage temp.: −20°C
Water Solubility: Insoluble
refractive index: 1.5100 (estimate)
pka: 14.91±0.70(Predicted)
BRN: 2224615

分析项目

SPECIFICATION PROPERTIES

技术指标

STANDARD

实测结果

RESULTS

外观

Appearance

白色或微黄色结晶粉末

White or yellowish crystalline powder

微黄色结晶粉末

Light yellow crystalline powder

吸光度Absorbance

< 0. 150 /420 nm

(c = 1. 00 g /100 mL CHCl3

0.02

含量

Assay

≥90(HPLC)

90.04%

干燥失重 Loss on drying%

≤17

7.71%

熔点 M.P.

≥140℃

144.2-146.7℃

7-Dehydrocholesterol Usage And Synthesis
Chemical Propertieswhite to off-white fine crystalline powder
UsesA vitamin precursor.
Vitamin D3 is produced by the action of sunlight or ultraviolet irradiation from the precursor, 7-dehydrocholesterol (7-DC), that is synthesized in the skin of animals and humans.
In most tissues of the body, 7-dehydrocholesterol is the immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS. 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944. 7-DHC is a provitamin that is converted to vitamin D3 by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.
Uses7-Dehydrocholesterol (7-DHC), a 5,7-conjugated diene sterol is a biosynthetic precursor of cholesterol. It helps in the production of vitamin D3 when exposed to ultraviolet B (UVB) radiation. 7-Dehydrocholesterol has been used as an internal standard to determine sterols.
7-dehydrocholesterol is used in the diagnosis of Smith-Lemli-Opitz syndrome. Blood and tissue of infants with Smith- Lemli-Opitz (SLO) syndrome contain reduced amounts of cholesterol and greatly increased concentrations of 7-dehydrocholesterol and of its isomer 8-dehydrocholesterol.


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