Tianeptine sodium salt CAS 30123-17-2

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Tianeptine sodium salt CAS 30123-17-2

Tianeptine sodium salt CAS 30123-17-2 Basic information

Product Name: Tianeptine sodium salt
Synonyms: TIANEPTINE SODIUM;TIANEPTINE SODIUM SALT;7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic Acid S,S-Dioxide Sodium Salt;S-1574;Stablon;7-[(3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine-11-yl)amino]heptanoic ac
CAS: 30123-17-2
MF: C21H24ClN2NaO4S
MW: 458.93
EINECS: 250-059-3
Product Categories: chemical;Stablon, Coaxil, Tatinol;Intermediates & Fine Chemicals;Pharmaceuticals;API;Inhibitors;Heterocycles;Sulfur & Selenium Compounds
Mol File: 30123-17-2.mol

Tianeptine sodium salt CAS 30123-17-2 Chemical Properties

Melting point: 1800C
form: solid
storage temp.: Desiccate at RT
color: white to tan
solubility: DMSO: ≥20mg/mL
Merck: 14,9420

Product

产品名称

Tianeptine sodium

噻奈普汀钠

Batch No.

批号

20190410

Mfg. Date

生产日期

20190410

CAS No.

30123-17-2

Exp. Date

有效期至

20210409

Tests

项目

Results

结果

Specifications

标准

Description

性状

Off-white powder,very hygroscopic.

类白色粉末,极易引湿

White to yellowish powder,very hygroscopic.

白色或淡黄色粉末,极易引湿

Solubility

溶解度

Complies

符合要求

Freetly soluble In water and methanol and dichloromethane

在水、甲醇和二氯甲烷中易溶

 

Identification

鉴别

Complies

符合要求

1By IR, To match with working standard

IR 图谱应与对照品一致

Complies

符合要求

2It gives reaction of sodium

应显钠盐的鉴别反应

Impurities A

杂质 A

Not detected

未检出

≤0.1%

Related compounds

有关物质

0.1%

Any impurity 任意杂质 ≤0.1%

0.19%

Total impurities 总杂质 ≤0.4%

 

 

 

 

 

Residual Solvents

溶剂残留

Not detected

未检出

Acetidin 乙酸乙酯≤ 0.5%

0.04%

Dichloromethane 二氯甲烷≤ 0.06%

0.01%

Methanol 甲醇≤ 0.3%

0.01%

Acetone 丙酮≤ 0.5%

Not detected

未检出

Acetonitrile 乙腈≤0.041%

0.01%

Ethanol 乙醇≤0.5%

Not detected

未检出

N, N-dimethylformamide N,N-二甲基甲酰胺

≤0.088%

Water

水分

2.35%

≤ 5.0%

Assay

含量

99.35%

99.0%-101.0%On anhydrous basis 以干品计)

Conclusion 结论 : Conform to EP8.0 本品符合 EP8.0 标准

 

 

Exam WuXiaoqiang Analyst ZhouLin Checker WangHailong


UsesTianeptine sodium salt hydrate has been used as a selective serotonin reuptake enhancer (SSRE) positive control during serotonin transporter (SERT) assay in human embryonic kidney 293 cell lines.
Laboratory ProceduresTianeptine (sodium salt) is supplied as a crystalline solid. A stock solution may be made by dissolving the tianeptine (sodium salt) in the solvent of choice. Tianeptine (sodium salt) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of tianeptine (sodium salt) in these solvents is approximately 10, 20, and 30 mg/ml, respectively. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of tianeptine (sodium salt) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of tianeptine (sodium salt) in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.
DescriptionTianeptine sodium is a structurally novel, serotonin specific antidepressant. It is useful in the treatment of neurotic and reactive depressions, as well as depressive states accompanied by anxiety.
Chemical PropertiesWhite to Yellowish Powder
OriginatorSci. Union et Cie (France)
UsesTricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant
UsesTianeptine (INN) (Stablon, Coaxil, Tatinol) is a selective serotonin reuptake enhancer (SSRE) drug used for treating major depressive episodes (mild, moderate, or severe). Unlike conventional tricyclic antidepressants, tianeptine enhances the reuptake of


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