Cidofovir CAS 149394-66-1

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Cidofovir CAS 149394-66-1

Cidofovir CAS 149394-66-1 Basic information

Product Name: Cidofovir
Synonyms: Cidofovir hydrate;Drg-0145;Gs-0504;Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, dihydrate, (S)-;Unii-jil713Q00n;(S)-[1-(4-AMino-2-oxo-pyriMidin-1(2H)-yl)-3-hydroxy-propan-2-yl]oxyMethylphosphonic acid dihydrate;
CAS: 149394-66-1
MF: C8H14N3O6P
MW: 279.187021
EINECS: 814-987-8
Product Categories: Anti-virals;Heterocyles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Amines
Mol File: 149394-66-1.mol

Cidofovir CAS 149394-66-1 Chemical Properties

     TESTS  

        SPECIFICATION 

   RESULTS  

Description

White or off-white crystalline powder

White powder

Solubility

Slightly Soluble in water,practically insoluble in

methanol,practically insoluble in ethyl aceteta.

Conforms

Identification

The infrared adsorption spectrum corresponds to that of reference standard.

Conforms

PH

3.0 to 3.8

3.20

Specific rotation

-78°~-95°

-87.1°

Water

10.0% to 12.5%

11.96%

Chlorides

Not more than 0.01%

Conforms

Heavy Metals

Not more than 10ppm

Conforms

Related substance Impurities

 

Individual: Not more than 0.10%

0.02%

Total: Not more than 0.50%

0.03%

e.e.value

>99.8%

100.0%

Assay

98.0~102.0%

99.98%

Methanol

Not more than 3000ppm

Not detected

Ethanol

Not more than 5000ppm

Not detected

Acetone

Not more than 5000ppm

Not detected

Ethyl acetate

Not more than 5000ppm

Not detected

Tetrahydrofuran

Not more than 720ppm

Not detected

N,N-dimethylforma mide

Not more than 880ppm

Not detected

Pyridine

Not more than 200ppm

Not detected

Dichloromethane

Not more than 600ppm

Not detected

Benzene

Not more than 2ppm

Not detected

CONCLUSION

COMPLIES WITH THE IN HOUSE STANDARD


Cidofovir Usage And Synthesis
Chemical PropertiesWhite Solid
UsesAn injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefo re prevention of viral replication and transcription. It is used in the treatment of acyclovir resistant herpes as well as a complementary intralesional therapy against papillomatosis caused by human papillomavirus (HPV).
DefinitionChEBI: The dihydrate of the anhydrous form of cidofovir. A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.
Brand nameVistide (Gilead Sciences).


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