Cidofovir CAS 149394-66-1 Basic information
Product Name: | Cidofovir |
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Synonyms: | Cidofovir hydrate;Drg-0145;Gs-0504;Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, dihydrate, (S)-;Unii-jil713Q00n;(S)-[1-(4-AMino-2-oxo-pyriMidin-1(2H)-yl)-3-hydroxy-propan-2-yl]oxyMethylphosphonic acid dihydrate; |
CAS: | 149394-66-1 |
MF: | C8H14N3O6P |
MW: | 279.187021 |
EINECS: | 814-987-8 |
Product Categories: | Anti-virals;Heterocyles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Amines |
Mol File: | 149394-66-1.mol |
Cidofovir CAS 149394-66-1 Chemical Properties
TESTS | SPECIFICATION | RESULTS |
Description | White or off-white crystalline powder | White powder |
Solubility | Slightly Soluble in water,practically insoluble in methanol,practically insoluble in ethyl aceteta. | Conforms |
Identification | The infrared adsorption spectrum corresponds to that of reference standard. | Conforms |
PH | 3.0 to 3.8 | 3.20 |
Specific rotation | -78°~-95° | -87.1° |
Water | 10.0% to 12.5% | 11.96% |
Chlorides | Not more than 0.01% | Conforms |
Heavy Metals | Not more than 10ppm | Conforms |
Related substance Impurities
| Individual: Not more than 0.10% | 0.02% |
Total: Not more than 0.50% | 0.03% | |
e.e.value | >99.8% | 100.0% |
Assay | 98.0~102.0% | 99.98% |
Methanol | Not more than 3000ppm | Not detected |
Ethanol | Not more than 5000ppm | Not detected |
Acetone | Not more than 5000ppm | Not detected |
Ethyl acetate | Not more than 5000ppm | Not detected |
Tetrahydrofuran | Not more than 720ppm | Not detected |
N,N-dimethylforma mide | Not more than 880ppm | Not detected |
Pyridine | Not more than 200ppm | Not detected |
Dichloromethane | Not more than 600ppm | Not detected |
Benzene | Not more than 2ppm | Not detected |
CONCLUSION | COMPLIES WITH THE IN HOUSE STANDARD |
Cidofovir Usage And Synthesis |
Chemical Properties | White Solid |
Uses | An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefo re prevention of viral replication and transcription. It is used in the treatment of acyclovir resistant herpes as well as a complementary intralesional therapy against papillomatosis caused by human papillomavirus (HPV). |
Definition | ChEBI: The dihydrate of the anhydrous form of cidofovir. A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. |
Brand name | Vistide (Gilead Sciences). |