Gadodiamide CAS 131410-48-5

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Gadodiamide CAS 131410-48-5

Gadodiamide CAS 131410-48-5 Basic information

Product Name: Gadodiamide
Synonyms: 2-[bis[2-[carboxylatomethyl-[2-(methylamino)-2-oxoethyl]amino]ethyl]amino]acetate;Gd-DTPA-BMA;S-041;GADODIAMIDE (500 MG);gadolinium 2-[bis[2-(carboxylatomethyl-(methylcarbamoylmethyl)amino)ethyl]amino]acetate;GADODIAMIDE;Omniscan;[5,8-Bis(carboxymethyl)-1
CAS: 131410-48-5
MF: C16H26GdN5O8
MW: 573.658
Mol File: 131410-48-5.mol

Gadodiamide CAS 131410-48-5 Chemical Properties

form: powder
color: white

Item

Specifications

Results

Appearance

White powder

Conforms

Identification

A: Infrared absorption should conforms with the standard apectrum

Conforms

B: The maximum absorption at the relevant wavelength specified

Conforms

Clarity of Solution

Not more opalescent than the Reference solution

Conforms

Water content

3.0%-14.0%

12.4%

Limit of free gadolinium(III)

Not more than 0.3%

Not detected

Limit of free Diethylenetramine pentaacetic aoid bismethylamine

Not more than 0.7%

(anhydrous basis)

0.01%

Limit of methylamine

Not more than 0.05%

0.007%

Limit of acetone, ethylalcohol, isopropyl alcohol

Acetone

Not more than 0.2%

0.09%

Ethyl alcohol

Not more than 0.2%

Not detected

Isopropyl alcohol

Not more than 0.2%

Not detected

Total impurity

Not more than 0.2%

0.09%

Related compounds

Impurity A

Not more than 2.0%

0.191%

Impurity B

Not more than 2.0%

Not detected

Individual Impurity

Not more than 0.2%

0.05%

Total Impurity (except of Impurity A&B)

Not more than 0.5%

0.09%

Content of gadolinium

26.0-29.0%

28.4%

Microbiological purity

Bacterial

500cfu/g

complies

Mould and yeast

50cfu/g

complies

Escherichia coli

Not detected

Not detected

Bacterial endotoxin

 3.5EU/g

complies

Assay on dried(C16H26GdN5O8)

97%-103.0%

98.9%

Conclusion

Complies with requirement of USP40 Standard

 

Gadodiamide Basic information
Product Name:Gadodiamide
Synonyms:2-[bis[2-[carboxylatomethyl-[2-(methylamino)-2-oxoethyl]amino]ethyl]amino]acetate;Gd-DTPA-BMA;S-041;GADODIAMIDE (500 MG);gadolinium 2-[bis[2-(carboxylatomethyl-(methylcarbamoylmethyl)amino)ethyl]amino]acetate;GADODIAMIDE;Omniscan;[5,8-Bis(carboxymethyl)-11-[2-(methylamino)-2-oxoethyl]-3-oxo-2,5,8,11-tetraaza-tridecan-13-oato(3-)]gadolinium
CAS:131410-48-5
MF:C16H26GdN5O8
MW:573.658
EINECS:
Product Categories:
Mol File:131410-48-5.mol
Gadodiamide Structure

Gadodiamide Chemical Properties
CAS DataBase Reference131410-48-5

Safety Information
HS Code 2846909000
Hazardous Substances Data131410-48-5(Hazardous Substances Data)
ToxicityLD50 i.v. in mice: 14 mmol/kg (Chang)

MSDS Information

Gadodiamide Usage And Synthesis
Usesefers to the substance containing the water of coordination and multiple (x) waters of hydration.
DefinitionChEBI: A non-ionic gadolinium chelate having a macrocyclic triamine framework. It is used as a paramagnetic contrast agent in magnetic resonance imaging (MRI).
General DescriptionGadodiamide is a clear,colorless to slightly yellow, gadolinium-based contrastagent indicated to visualize lesions with abnormal vascularityin the CNS and body. It is a nonionic gadoliniumcomplex administered by intravenous injection with an osmolalityof 2.8 times that of plasma. Gadodiamide decreasesboth the T1 and T2 relaxation times in tissueswhere it is distributed. In clinical MRI, the effect is primarily on the T1 relaxation time resulting in an increase inT1-weighted sequence signal intensity.




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