Aristolochic acid C2CAS:313-67-7

  • Product Name:Aristolochic acid
  • CAS:313-67-7
  • Molecular formula:C17H11NO7
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Aristolochic acid C2CAS:313-67-7

Aristolochic acid C2CAS:313-67-7 Basic information

Product Name: Aristolochic acid
Synonyms: Aristolochic acid Ⅰ;nsc-50413;tardolyt;8-METHOXY-6-NITROPHENANTHROL(3,4-D)-1,3-DIOXIDE-5-CARBOXYLIC ACID;ARISTOLOCHIC ACID;ARISTOLOCHIC ACID A;ARISTOLOCHIC ACID I;8-methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid
CAS: 313-67-7
MF: C17H11NO7
MW: 341.27
EINECS: 206-238-3
Product Categories: reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles;chemical reagent;pharmaceutical intermediate;phytochemical
Mol File: 313-67-7.mol

Aristolochic acid C2CAS:313-67-7 Chemical Properties

density: 1.3162 (rough estimate)
Melting point: 260 °C
Boiling point: 476.92°C (rough estimate)
form: powder
storage temp.: 2-8°C
refractive index: 1.4500 (estimate)
pka: 2.99±0.20(Predicted)
InChIKey: LIDQMWRBMLSXLL-UHFFFAOYSA-N
solubility: DMSO: soluble
CAS DataBase Reference: 313-67-7(CAS DataBase Reference)

Test

 

 

PURITY(HPLC)

Min. 98

Specification

 

Max.

 

100

APPEARANCE


Yellow powder


INFRARED SPECTROMETRY


Conforms to Structure


Aristolochic acid Usage And Synthesis
Chemical PropertiesShiny brown leaflets or a yellow or white powder.
UsesPLA2 inhibitor
UsesAristolochic acids occur in Aristolochiaceae and in butterflies feeding on these plants. One of a group of fourteen known, substituted 1-phenanthrenecarboxylic acids
DefinitionChEBI: A monocarboxylic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is b th carcinogenic and nephrotoxic.
Brand nameAcidum aristolchicum;Descresepet;Fago-araxin;Fluocinova;Predno-facilus haemota.
World Health Organization (WHO)Extracts of aristolochiaceae have traditionally been used as a bitter for which a broad range of therapeutic effects has been claimed. Aristolochic acid is claimed to promote phagocytosis and to have immunostimulant activity. However, in 1981, a three-month toxicity study in rats revealed the carcinogenic potential of aristolochic acid and preparations containing this substance have since been withdrawn in several countries.
Safety ProfileConfirmed carcinogen. Poison by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO,. Potentially Toxic Chemicals: April 1982." Vol. 5 No. 1: The Ministry of Health of the Federal Republic of Germany has withdrawn from the national market drugs containing aristolochic acid. The decision resulted from the demonstration of a carcinogenic potential in a three-month ingestion toxicity study undertaken in rats. Aristolochic acid is claimed to promote phagocytosis and to have immunostimulant activity. A growth-inhibiting effect on experimentally induced tumors has been described, but this effect has not been shown to have any clinical relevance. Extracts of species of Aristolochiacea have tradtionally been used as a bitter, and a broad range of therapeutic effects has been claimed.
Potential ExposureAristolochic acids are alkaloids used primarily as a chemical intermediate for pharmaceuticals, lab chemicals, herbal extract, drug.
ShippingUN1544 Alkaloids, solid, n.o.s. or Alkaloid salts, solid, n.o.s. poisonous, Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required. PG III.
IncompatibilitiesCompounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste DisposalIt is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. All federal, state, and local environmental regulations must be observed.


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