Methylene Blue CAS:61-73-4

  • Product Name:Methylene Blue
  • CAS:61-73-4
  • Molecular formula:C16H18ClN3S
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Methylene Blue CAS:61-73-4

Methylene Blue CAS:61-73-4 Basic information

Product Name: Methylene Blue
Synonyms: METHYLENE BLUE SOLUTION, 0.5% IN WATER;METHYLENE BLUE SOLUTION ALKALINE ACC. TO LOEFFLER;METHYLENE BLUE SOLUTION ACCORDING TO LOE FFLER FOR MICROSCOPY;METHYLENE BLUE CERTIFIED (C.I. 52015) FOR STAINING AND REAGENT FOR SPECTROSCOPY USE;METHYLENE BLUE INDI
CAS: 61-73-4
MF: C16H18ClN3S
MW: 319.85
EINECS: 200-515-2
Product Categories: Analytical reagent;Indazoles;Analytical Chemistry;Ion Association;Phenothiazine
Mol File: 61-73-4.mol

Methylene Blue CAS:61-73-4 Chemical Properties

density: 1.0 g/mL at 20 °C
Melting point: 190 °C (dec.)(lit.)
form: Liquid
storage temp.: Store at RT
Water Solubility: 40 g/L (20 ºC)
refractive index: n20/D1.347
pka: 2.6, 11.2(at 25℃)
BRN: 3641570
Fp: 45 °C
solubility: Soluble in water, ethanol, ethylene glycol, methyl cellosolve
NIST Chemistry Reference: Methylene blue(61-73-4)
Merck: 14,6060
Specific Gravity: 0.98
Odor: Odorless
λmax: 661 nm
Colour Index: 52015
EPA Substance Registry System: Methylene blue (61-73-4)

Item

Specification

Appearance

Green Crystalline Powder

Ash

NMT 0.5%

Loss on Drying

NMT 15.0%

Purity

NLT 98.0%

Methylene Blue Usage And Synthesis
Chemical Propertiesgreen fine crystalline powder
UsesA useful inhibitor of cGMP-mediated processes and a useful stain
DefinitionChEBI: An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties.
HazardToxic by ingestion.
Biological ActivityBiological stain and redox indicator. Inhibits tau filament formation (IC 50 = 1.9 μ M). Also inhibits soluble guanylyl cyclase.
Clinical UseMethylene blue is 3,7-bis(dimethylamino)-phenazathioniumchloride (Urised). The compound occurs as a dark greencrystalline powder with a metallic appearance that is solublein water (1:25) and alcohol (1:65).
Methylene blue has weak antiseptic properties that makeit useful for the treatment of cystitis and urethritis. The actionof methylene blue is considered to be bacteriostatic.The compound colors the urine and stool blue green.
Safety ProfilePoison by ingestion,intraperitoneal, intravenous, and subcutaneous routes.Human systemic effects: cyanosis, blood changes.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits verytoxic fumes of NOx, SOx, and
Veterinary Drugs and TreatmentsMethylene blue is used primarily for treating methemoglobinemia secondary to oxidative agents (nitrates, chlorates) in ruminants. It is also employed occasionally as adjunctive or alternative therapy for cyanide toxicity.
Intra-operative methylene blue is also being used to preferentially stain islet-cell tumors of the pancreas in dogs in order to aid in their surgical removal or in determining the animal’s prognosis.
Purification MethodsCrystallise the chloride from 0.1M 664 2HCl (16mL/g), the crystals are separated by centrifugation, washed with chilled EtOH and diethyl ether, and dried under vacuum. Crystallise it from 50% aqueous EtOH, wash it with absolute EtOH, and dry it at 50-55o for 24hours. It has also been crystallised from *benzene/MeOH (3:1). It has been salted out with NaCl from a commercial concentrated aqueous solution, then crystallised from water, and dried at 100o in an oven for 8-10hours. [Beilstein 27 III/IV 5152.]


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