Minocycline hydrochloride CAS:13614-98-7

  • Product Name:Minocycline hydrochloride
  • CAS:13614-98-7
  • Molecular formula:C23H28ClN3O7
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Minocycline hydrochloride CAS:13614-98-7

Minocycline hydrochloride CAS:13614-98-7 Basic information

Product Name: Minocycline hydrochloride
Synonyms: Minoxycline;tri-mino;tri-minocycline;MYNOCINE;MINOCYCLINE HYDROCHLORIDE;MINOCYCLINE HCL;MINOCIN;7-DIMETHYLAMINO-6-DEMETHYL-6-DEOXYTETRACYCLINE, HCL
CAS: 13614-98-7
MF: C23H28ClN3O7
MW: 493.94
EINECS: 237-099-7
Product Categories: DAYPRO;antibiotic;API;Antibacterial;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;Peptide Synthesis/Antibiotics
Mol File: 13614-98-7.mol

Minocycline hydrochloride CAS:13614-98-7 Chemical Properties

Melting point: 205-210° (dec)
Boiling point: 813℃
form: crystalline
storage temp.: 2-8°C
Water Solubility: Freely soluble in water
InChIKey: GLMUAFMGXXHGLU-VQAITOIOSA-N
Fp: >110°(230°F)
solubility: Sparingly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and carbonates.
Merck: 14,6202
Stability: Light Sensitive
CAS DataBase Reference: 13614-98-7(CAS DataBase Reference)

溶解度

Solubility

甲醇中溶解,在水中略溶,在乙醇中微溶,在乙醚中几乎不溶

Dissolved in methanol, slightly soluble in water, slightly soluble in ethanol, almost insoluble in ether

符合规定

Conform

结晶性 Crystallinity

符合规定 Conform

符合规定 Conform

酸碱度 PH

3.54.5

4.0

干燥失重 Loss on drying

4.3%8.0%

7.0%

炽灼残渣 Residue on ignition

0.5%

0.02%

重金属 Heavy metal

50ppm

50ppm

差向米诺环素 Epi-minocycline

1.2%

符合规定 Conform

单杂Single impurity

1.0%

0.32%

总杂 Total impurity

2.0%

0.59%

含量(含米诺环素)

89.0-95.0%

92.64%

AssayContaining minocycline




UsesSecond generation tetracycline antibiotic. Antibacterial.
Usesantiinflammatory
UsesMinocycline hydrochloride is a salt prepared from minocycline, taking advantage of the two basic dimethylamino groups which protonate and readily form a salt from hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, minocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.


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